Endocrine Abstracts

Introduction and aims: Autophagy is an essential process for cell homeostasis that implies recycling and degradation of damaged organelles and long-lived proteins. It is induced during caloric restriction (in order to obtain energy) or other stress-inducing conditions. Autophagy is initiated by autophagosome formation, a double-membrane vesicle which engulfs cellular components and delivers them for degradation by fusing with lysosomes. Thus, proper autophagy regulation favour...

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

Background and aimsLifestyle modifications based on diet and exercise are common strategies for the treatment and prevention of obesity and related comorbidities. However, not all patients respond equally to similar weight loss intervention which compromise patient adherence. Strategies for predicting the individual response are required for improving intervention efficiency by personalized recommendations. microRNAs (miRNAs), small RNA particles which r...